You may have a compromised host as it appears a computer on your network is making requests to known Malware domains. First you need to find out which hosts are making these requests. Analysis->Intrusion Events should show you the events in question. (Be aware that it may show your local DNS server making the request on behalf of a host and not the original client who is compromised that made the request.) After locating which IPs are compromised you should wipe those PCs/Servers or at the very least clean with AV (though the later may leave undetectable software installed.)