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At OC3 bandwidths, Cisco and 3rd party solutions really address WAN acceleration, of which compression is often a part. However, for just using those for compression, you might find they are not inexpensive.
Another approach, is "management" of your bandwidth with QoS. If your application bandwidth needs differ, you may find you have "ample" bandwidth, even with links running at 100%. Year ago, I had a set of E3s that ran at 100% all during business hours, and had everything on them from VoIP to server backups. Users didn't complain because I had sufficient bandwidth to satisfy application requirements.
