As of February 15th, 2014, Trend Micro changed the signing certificate used to digitally sign the pattern updates used by the Trend Micro Content Security and Control Module (CSC-SSM). This causes the CSC module to fail to 'verify' the downloaded patterns and results in updates failing. Administrator would be presented with an email notification along the line of:
AntiVirusPattern : Pattern Update: The download file was unsuccessful for ActiveUpdate was unable to verify security information. The local trusted info database is corrupted. Please contact Trend Micro technical support.. The error code is 62.
This issue is addressed by CSC Module patch 1145 (or later) for version 6.6.1125.0 of the CSC Module code.
You can obtain Patch 1146 from Trend Micro's Safe Sync server at the following URL:
https://dc1.safesync.com/LMcmmxjs/csc_66_en_hfb1146.zip?a=LkkaMTwupGE
The zip file contains two files, the MD5 sums of the files are listed here for reference:
MD5 (Readme.txt) = 5c6127c0abffa4634fc2908b775eec30
MD5 (csc_66_en_hfb1146.pkg) = bfc98940f19eb7e6d2177615d553fb74
The above patches have been superseded by patch versions x.1169. More information here: https://supportforums.cisco.com/document/13102616/csc-module-updates-failing-after-late-july-2016-error-code-28
The included readme.txt file contains the release notes for this Hotfix.
Application of the Hotfix patch is done through the CSC Module GUI in the 'Product Upgrade' section of 'Administration':

If you continue to have pattern update failures, please contact Cisco TAC.