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@Simes-Kearn understood. You mentioned the ASA is a cluster (I assume you meant HA pair) - they will need L2 connectivity between them, so you cannot remove the switch.
@Simes-Kearn what is the reasoning for doing this? It seems over complicated.
You'd need routing setup correctly, to route in and out the correct interfaces, but it could work. Are you having a particular problem?
@joly you could possibly try using the command "show tech | begin “Displaying ISE Profile“" to determine what the original profile was, thus what the original deployed OVA spec was.
Use the ISE performance and scale guides to determine what size you ...