Hi,
If you're following the VPN wizard on ASDM, you should get asked about the protected networks that are going to be communicating through the tunnel (ACLs).
After the wizard finishes it will show the configuration that is going to be applied for this tunnel.
There are several kind of ACLs that you should be concerned about.
Crypto ACLs --> to encrypt the traffic between sites
NAT ACLs --> to define which traffic is going to be exempt from NAT (interesting traffic)
Interface ACLs --> to permit traffic to flow through the interface
VPN traffic is by default exempt of being check by the outside interface ACL so you don't need to worry about it.
If you're doing everything from the CLI you should pay close attention to all the commands and ACLs, but if just following the wizard via ASDM, then the ASA should pretty much create the configuration that you need for you (obviosuly this depends on what configuration is already in place in the ASA).
Hope it helps.
Federico.