Hi,
You can do a policy based static translation to NAT the traffic only over the VPN tunnel.
Suppose your source subnet is s.s.s.0/24, destination d.d.d.0/24 ant NATed subnet is n.n.n.0/24, the following commands will achieve policy static NAT
Access-list vpn-nat permit ip s.s.s.0 255.255.255.0 d.d.d.0 255.255.255.0
Static (inside,outside) n.n.n.0 access-list vpn-nat
Dont forget to change the crypto access-lists at both ends to match the change in IP also.
Access-list crypto-acl permit ip n.n.n.0 255.255.255.0 d.d.d.0 255.255.255.0
HTH
Regards,
Shijo George.