We did that recently (after so many struggles with SNAT) from css11501 to ACE (6506 MSFC)...
SNAT Issues - Fixed it after cisco suggested to configure SLB, SNAT both under one single policy..
Active/Standby Config Sync issues (maybe it is due to the huge config what we have..around 15000 lines.)
Manageability thru GUI (ANM Server takes forever to modify any changes..