Hello Daniele,
here are my comments:
Can I use two NME-WAE-502 for a point-to-point WAN, one as edge and one as core ?
There is no restriction where to install them but these are design mainly for branch offices, my suggestion is to give your best guess and estimate number of users, applications, bandwidth and take the time to check the design guides as well. Request assistance to your Cisco Partner too.
some details about the module:
NME-WAE-502
Max Optimized TCP Connections: 500
Max CIFS Sessions: 120
Max Recommended WAN Link [Mbps]:4
further details can be found on the design guide
http://www.cisco.com/en/US/docs/solutions/Enterprise/Data_Center/WAASDC11.html
Is it also possible to use them without the Central-Manager ?
WAAS continues to function in the event of CM failure, but you need it for configuration changes, monitoring, statistics, software updates...etc.
hope that helps,
Felix