I figured it was worth a shot to ask here if anyone had any ideas on how to protect against these type of exploits.
Advisory: http://www.adobe.com/support/security/advisories/apsa11-02.html
Article: http://www.theregister.co.uk/2011/04/12/attacks_exploit_adobe_flash/
Even thought the vulnerability is being exploited in targeted malware attacks, Adobe states that a patch will not be "available" until June 14th. We will rely on desktop level protection when definitions are updated since the flash is embedded in MS Word docs (likely others will be added to the list...pdf, xls, etc.).
Some of the attacks are coming from a known IP address range which we can quarantine, but does anyone else have any other ideas while we wait on Adobe? Thanks in advance!