Please use the admin guide to assist you for setup/configuration:
http://www.cisco.com/c/dam/en/us/td/docs/security/esa/esa8-0/user_guide/ESA_8-0-1_User_Guide.pdf
On the VESA - the Recipient Access Table (RAT) will control which domains your appliance accepts for.
AsyncOS uses a Recipient Access Table (RAT) for each public listener to manage accept and reject actions for recipient addresses. Recipent addresses include these:
•Domains
•Email addresses
•Groups of email addresses
This is covered in detail in the "Overview of Accepting or Rejecting Connections Based on the Recipient’s Address" section.
Please see the "Configuring the Gateway to Receive Email" section for configuration of appliance for domains.
Please see the "Defining Which Hosts Are Allowed to Connect Using the Host Access Table (HAT)" section for configuration of appliance for sending.
I hope this helps!
-Robert
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