When the authentication fails TWICE in a 5 minutes period the SUPPRESSION LIST is triggered to cancel repeated failed transactions BUT after 3 more failed authentications during the same period of time, your MAC is placed in that list for 5 minutes. In fact, you can keep trying and still fail until your AD account is locked. ISE basically ignores additional data from failed authentications. At some point you can unlocked your AD account but your MAC would be still in that list and therefore retrying authentication would fail. Use the Suppresion Bypass to remove the MAC from the Internal ISE suppression list so you can try to reconnect immediately.
However, if the enduser devices keeps sending wrong credentials after the account was unlocked, then the situation remains the same. The wireless network must be forgotten on the enduser device, AD account unlocked, wait until the suppression list timer expires (or use bypass suppression) and THEN try to reconnect.
Global Suppression mechanism tries to avoid overloading ISE from a misbehaving supplicant (it is similar to the EXCLUSION LIST on the WLC). It has nothing to do with the authentication process. It also reduces the amount of accounting updates generated by that anomalous supplicant.
Bypass Suppression actually means = remove my MAC from the suppression list immediately so I can retry to authenticate.
