This required more of analysis hop by hop, is this really causing of NAT or any other part of the Network.
1. Do you have NMS ? you monitor links? do you see any overload or packet drops?
2. how is your network from FTD to Server? what devices in between - this required to verify.
3. at the time of the issue, do you see the same issue locally?
4. at the time of issue what is the other side of network usage ? do you have any visibility?
5. is this issue only for that VPN ? or any other VPN or users?
check the NAT and troubleshoot :
https://www.cisco.com/c/en/us/support/docs/security/firepower-management-center/212702-configure-and-verify-nat-on-ftd.html
Troubleshoot to capture information for analysis :
https://www.cisco.com/c/en/us/support/docs/security/firepower-ngfw/215092-analyze-firepower-firewall-captures-to-e.html