If there is no fix pattern for the username field in RPC or if its encrypted (via NTLM hash etc.) then there is no chance you can match it using regex.If the field is predictable, then a custom signature can be made as desired.
The MARS box does not do any detection or regex matching itself, it just correlates the signature events received from the IPS, so I doubt MARS would help here.
Regards
Farrukh