Hi,
It depends upon the connector. For example below is the Pin Out for a standard RJ45.
1 | RX (input) |
2 | RX (input) |
3 | -- |
4 | TX (output) |
5 | TX (output) |
6 | -- |
7 | -- |
8 | -- |
Below is the link.
http://www.cisco.com/c/en/us/support/docs/routers/1600-series-routers/46795-wic-1dsu-t1.html
If it is being connected to another RJ45 via T1 link, Tx and Rx pair has to be interchanged.

HTH
-Amit