Hi,
From the description of your issue it seems like the problem is not on the ASA nor the VPN configuration, seems more like an internal routing issue. The VPN clients will get an IP within the 10.10.50.0/24 range, does the 192.168.5.253 host have a route for the 10.10.50.0 network pinting to the internal interface IP of the ASA that is facing this network?
Please share the ASA configuration and also try to setup a packet capture on the inside interface of the ASA so we can make sure the traffic is leaving for the internal network, this will also tell us if we are getting replies from the internal network.