Hello,
Are you saying that there is only ONE link from one FI (let´s say FI-A) to the 4500 and the other FI (FI-B) has no links to the upstream switch?
Servers cannot communicate to each other when you ping each other´s management IP/OS IP/VM´s IPs?
I think the issue might be that the Cat4500 does not support VN-Link (Now called VM-FEX or Adapter FEX), which basically allows the switch (VN-Link capable, e.i Nexus7K or Nexus5K) to understand that his phisical link is actually divided in 2 (or more) virtual interfaces, letting the switch send traffic back from the same physical interface it is receiving it on. A regular switch, not VN-Link capable, would normally drop a packet that has the same destination as its source to avoid a loop.
More information here:
* http://www.cisco.com/c/en/us/solutions/collateral/switches/nexus-1000v-switch-vmware-vsphere/white_paper_c11-525307.html
* http://www.cisco.com/c/en/us/td/docs/unified_computing/ucs/sw/gui/config/guide/1-3-1/b_UCSM_GUI_Configuration_Guide_1_3_1/UCSM_GUI_Configuration_Guide_1_3_1_chapter28.html
* http://www.cisco.com/c/dam/en/us/products/collateral/switches/nexus-1000v-switch-vmware-vsphere/at_a_glance_c45-532467.pdf
-Kenny