Hi Dan,
You can add AIM-IPS on the 2851 routers for you gateway level IPS services. You can add CSC content service module on the ASA's which will give you, Anti-SPAM,Anti-Phishing, Content Filtering, URL filtering etc. capabilities.
That should take care of perimeter based security. If you want the Host based security and the end-point security you can also think of putting CSA along with Cisco NAC solution.
-amit singh