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BTW, uplink ports also often support port aggregation, so that alone isn't always the decider.
It depends whether uplink ports are "special", and if they are, do you need the "special".
For example, on the 3750 series, the uplink ports are often modular transceiver ports, so if you need a fiber connection, you'll need to use one. However, also on the 3750 series, each bank of 24 copper ports has 2 MB of RAM, but so do the uplink ports. So, for a very busy copper port, an uplink port might be a better choice with a copper transceiver module vs. an ordinary copper edge port.