From VPN's perspective you only should look into avoiding fragmentation. The rest, VPN (is a service) is pretty agnostic as to what it's sending over as long as it's IP ;-)
The devices which are performing this VPN (firewalls ...) might have a different point of view.
Take care not to NAT that traffic, avoid fragmentiation and you should be fine.
Now for the wireless part, look into FlexConnect (or H-REAP as it was called before).
There's a few examples of CWA and LWA with FlexConnect if that's something you wanted to look into.