As of now, it is not.
Here is the Document.
10.5.2 still doesn't.
Strangely enough, 10.0 worked fine on Windows 10, but 10.5.2 doesn't.
Also, unrelated, 10.5.2(27) works poorly in general.
Come one Cisco, get your stuff together. It took ages to get a 64bit version and now Windows 10 is getting less than stellar support.
Yes, we also have some problems with Windows 10 and TSP 10.5. In some PC it is ok, others not okay. Strange....
It would be really helpful if this time give an official supported version.
TAPI 11.5 is compatible with Windows 10. Upgrade to cucm 11.5 if you want to use Windows 10.
Refer to the link below: