Other interfaces can be used for the various probes, like SPAN, DHCP, etc. Also for inline posture, you can see there are multiple interfaces needed when using high availability.
References:
ISE Config Guide - Configuring Probes (note the various probes that have an interface option)
http://www.cisco.com/en/US/partner/docs/security/ise/1.1.1/user_guide/ise_prof_pol.html#wp1555646
Cisco Identity Services Engine User Guide, Release 1.1.1, Setting up Inline Posture
Figure 10-4 Inline Posture Routed Mode High Availability Example
http://www.cisco.com/en/US/partner/docs/security/ise/1.1.1/user_guide/ise_ipep_deploy.html#wp1140749
Jatin Katyal
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~Jatin