So maybe I am totally misunderstanding the ask here since I am not a compliance expert but here goes:
ISO - which ISO standard?
PCI - ISE doesn't accept or handle credit card information so this seems to not apply here
HIPPA reports? ISE doesn't handle PHI so this seems to not apply here either
Data in motion - RADIUS is not an encrypted protocol; you can use RADIUS DTLS or IPSec if full encryption is needed for NAD traffic. TACACS+ is encrypted but uses what are considered weak algorithms by today's standards.
Data at rest - ISE does not encrypt its local disks