I believe so long as a block level storage device is presented to the VSMS server, and it's using XFS for a filesystem, it *should* be possible to get it to technically work. Another user on here reported some initial success with EXT4 on a block device, but I don't know how it turned out in the long run.
Another question altogether is whether or not Cisco TAC/PSBU will support it. I don't believe they will.
Best of luck... if you do any experimentation, I'd love to hear about it.
Cheers!
Scott Olsen
Solutions Specialist
Bulletproof Solutions Inc.
Web: www.bulletproofsi.com