Hi Praful,
I think you have many P2P application, like BT, EDonkey etc. Each NAT entry uses around 20 bytes of memory, router would run out os memory if sessions burst out in a high volume. So you need limit the nat entry number on router, try:
ip nat translation tcp-timeout 60
ip nat translation max-entries 70
You can tune tcp-timeout and max-entries smaller until it works fine.