I'm guessing you have a static NAT configured on your router.
before the software upgrade, if you were able to access your application on, for example, TCP port 4444, you probably had a static NAT configuration similar to this:
ip nat inside source static tcp <> 4444 interface <> 4444
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now after the upgrade, if the new TCP port was, for example, 5555, you would need to run these commands:
no ip nat inside source static tcp <> 4444 interface <> 4444
ip nat inside source static tcp <> 5555 interface <> 5555