depends what you mean with "full"
new features will be developed and upgrade to new IOS may be needed to support this on any device.
but basically Yes trustsec is supported:
Comprehensive Security with Cisco TrustSec
The Cisco Catalyst 4500E Supervisor Engine 8-E is a validated component of the Cisco TrustSec® 2.1 architecture. This allows the Supervisor Engine 8-E to be transparently integrated into campus switching environments for a comprehensive security solution based on Cisco TrustSec. The Supervisor Engine 8-E is a foundational element of the Cisco TrustSec architecture with support for the following functionalities:<read details in the linked document>
