HI Scott,
Where should the TMSXE 3.0 server be located? TMS side or Exchange side of the deployment
The TMSXE server could be located anywhere where it can reach both the Exchange CAS server and the Cisco TMS over HTTP(s).
Are there any latency concerns we should be aware of with this model?
No, Outlook booking is asynchronous, latency won't matter.
Is an offsite hosted Exchange solution supported?
Such deployments have not been tested by the Collaboration Infrastructure BU, and are thus by definition not supported. However, as long as you are allowed to control the throtteling policy on the CAS server, I don't see any reason why it shouldn't work. But note that you probably won't get any assistance from the TAC in case the off-site Exchange solution breaks TMSXE.
Regards,
Kjetil