I've had a similar experience, though our users do have administrative rights on the PC, so my "fix" might not work for you. At any rate, I found that the user who installed CUPC ("User A") would run it fine, but another user (User B) had to right-click and do "Run as Administrator." Finally, I discovered that during the install, when the Microsoft Visual C++ 2005 Redistributable Package (x86) is installed, and certmgr.exe is apparently dropped in the %temp% folder of User A. When User B logs into CUPC, it tries to fire off certmgr. exe but can't. By letting User B have permission to the %temp% folder of User A, then User B could run CUPC without doing "Run as Administrator." In the future, I just plan to install CUPC when logged in as "User B".
Hope that helps.
