Hello,
I installed and uninstalled RSK on a lab server and did not have to reboot Unity for either.
I will speak a little further on the RSK issue. At times RSK and CSA will have issue and can cause the SNMP to have issue.
There are 3 bugs I'm aware of:
CSCsr47291 - CSA 5.2 causes SNMP and RSKdataservice to crash-
CSCsu09290 - CSA 5.2 agent causes Unity's RSKdataservice crash
CSCtf39345 - RSK does not work with CSA (This one is still unresolved and being looked at still by developers.
You can query these bugs on Cisco.com and use Bug Toolkit to get more info.
Thanks,
Scott