There is no NAT used on the interfaces
It can be NAT on that interface, no issue at all.
Are there "must do's" on outside interfaces used for Site to Site VPNs?
You could allow only ISAKMP and IPSec traffic from valid trusted IP addresses and the regular checks, nothing different from the usual.
Regards
Julio Carvajal
Senior Network Security and Core Specialist
CCIE #42930, 2xCCNP, JNCIP-SEC