By the community that you posted this question to, I'm guessing you're asking if Cisco supports Microsoft's Threat Management Gateway (a guess based on the first result returned by Google) with either Cisco Agent Desktop or CTI OS.
Cisco has a whitelist support model; they only support what they have explicitly tested. Everything that was tested with Contact Center Express is documented in the Compatibility Matrix. Only Cisco AnyConnect or the legacy IPsec clients have been tested and are therefore the only options supported. This is not to say that another VPN product won't work, you just can't turn to Cisco for help if it breaks.
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