I assume you are referring to the DNS servers used by server (i.e. at the platform level, you have configured DNS1, DNS2, and a domain for lookup). You can change those settings via command line; however, it will restart network and reboot to take effect. If you have virtualized the servers, then it will change the license MAC and you will need to rehost the licenses. Do the Publishers first on each application and make sure to check DB replication after applying the changes to all of the servers.
Hailey
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