A client asked this question. Below is how I responded:
Q: Will the NFFC for the 4500 series work with a SUP6-E/SUP6-LE?
A: NO.
Expanded Answer: The following installation guide http://www.cisco.com/en/US/docs/switches/lan/catalyst4500/hardware/installation/guide/78-14409-08/01intro.html indicates that the Netflow daughter card works on a Sup IV/V . The module is *also* slated for EOL/EOS - http://www.cisco.com/en/US/prod/collateral/switches/ps5718/ps4324/eol_c51-658769.html Not sold after Nov 8th of this year. Not shipped after Feb 6th next year.
I have never attempted to install one on a SUP6-E, but there is no documented capability of that SUP to do netflow, either natively or with a daughter card. I can NOT however find any explicit documentation stating it will not work – only lack of documentation stating it will.
Can anyone state specifically that it will or will not work? I suspect "no" based on how difficult it is to find either component on the same page, but I simply don't know.