Hi joelbev1 ,
Based on your scenario you need support on Merake integration with Cisco ISE .You can refer the below link
https://community.cisco.com/t5/security-knowledge-base/how-to-integrate-meraki-networks-with-ise/ta-p/3618650#toc-hId--1169356895
Regarding your question, using the default self-signed server certificate from Cisco ISE for Domain Laptops to authenticate is possible. However, it's essential to consider security implications when using self-signed certificates. Self-signed certificates may not be trusted by all devices and can potentially lead to security warnings for users.
A more recommended approach would be to obtain a valid certificate from a trusted Certificate Authority (CA) and import it into Cisco ISE for EAP Authentication. This ensures that the certificate is trusted by all devices, reducing the risk of security warnings and improving the overall security of the authentication process.
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You can also learn more about ISE through our live Ask the Experts (ATXs) session. Check out Cisco ATXs Resources [https://community.cisco.com/t5/security-knowledge-base/cisco-endpoint-security-ask-the-experts-resources/ta-p/4394492] to view the latest schedule for upcoming sessions, as well as the useful references, e.g. online guides, FAQs.
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Thanks ,
G.Srinivasan