If you are running the same Map hierarchy in both DNAC and Prime then best practice is to follow the DNAC/Prime Coexistence
It does say in that document that
So from that point no you cant have both working at same time.
If all your using Prime for is to get the Maps into CMX, there is always the option to do a manual export/import task but that would be reliant on the Map hierarchy being different between Prime and DNAC
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