Hi Scott,
As you have found finding info on Cisco MSE can be difficult, I have ran into several issues with MSEs in the past and it can get very frustrating.
If you are planning on running WIPS and CAS it it highly recommend that you run them on separate VM or appliances. I ran them both on the same VM server for years and never really had any real issues until version 8.0 came out. 8.0 caused the MSE to crash all the time, the logs on the MSE would fill up with "Core Crash logs" which I had to manually delete. I moved the WIPS and CAS to separate servers and everything stabilized.
8.0.130.0 is a stable version, do not run any 8.x version below this, they all have major issues.
8.0.140.0 is out but I have not upgraded yet, since it took me over a year to get a stable version of 8.0 code.
Make sure you pay attention to the server size you want to use. if you are requirements call for you to install a High-end vMSE , you must have the correct VM specs Cisco requires, The software may install but the licenses will not.
I hope this helps
David