This event is a chance to review how customers of all sizes face the same daunting challenge: email is simultaneously the most important business communication tool and the leading attack vector for security breaches. Cisco Secure Email enables users to communicate securely and helps organizations combat Business Email Compromise (BEC), ransomware, advanced malware, phishing, spam, and data loss with a multilayered approach to security.
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In Exchange, you will need to configure Send/Receive connectors based on the flow of traffic that you require. As an example, a Receive connector to accept mail being sent in from external > ESA > Exchange, and a send connector for outbound traffic going from Exchange > ESA > External.
For HA, it would depend on what you're referring to. The ESAs do not have any form of HA functionality builtin; however, you can configure them into a cluster to share configuration across devices. More information on that can be found here.
For actual high availability as far as mail traffic is concerned, you will want to configure DNS round-robin and/or have some form of load balancer in place within your network. Then, traffic can move between ESAs automatically if for some reason one is unreachable.