I was just configuring these for myself earlier today. I used the Real Time Monitoring tool (via the Servicability webpage). In 4.1. this is a downloadable tool. When you open the app once installed it asks you for your Mail Server Configuration.
There are a huge amount of alerts etc you can configure so please find the link to the RTMT admin guide: http://www.cisco.com/univercd/cc/td/doc/product/voice/c_callmg/4_1/service/serv413/ccmsrva/sartmt.htm
(this admin guide also forms part of the Call Manager serviceabiliy guide)
Hope this is what you were looking for.
If no access to CCO then the admin guides for RTMT are also available via Call Managers own online user guide.
Go to CCM Serviceability Admin Guide
Then Monitoring Tools Config
Then Real-Time Monitoring Config
Further info under the System guide.
The best and easiest Way is to do it with RTMT, another way is to use Windows Microsoft Performance tools; but you cant send email alerts with this one.
Choose Start > Programs > Administrative Tools > Performance.