We've run into this issue, mailhost is configured and testing fine, but Save and Email breaks, 3.4.1U1.   Unfortunately, the work around (Use the Save and Export option or set the scheduled job to write to disk.) also does not work. We get: "Failed t...

So the ISE Admin cert seems to map to port 80, 443, and 9060 for the ERS services. The portals are customizable (port and certificate group).   Question:  Is there a way for the ERS/9060 to be mapped to a certificate other than the Admin certificate?...