The short answer is maybe but not at all supported by Cisco. The phone is not RFC compliant (lots of Cisco-specific customizations) and you would need to manually build its TFTP config file. Even if you can get it to register to a third-party SIP Registrar making features on it work will be hit-and-miss.
More info here:
http://www.voip-info.org/wiki/view/Standalone+Cisco+7945/7965
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